A Painless, Micro Injection that One Can Do Oneself with Chula’s Latest Innovation “Detachable and Dissolvable Microneedles”

BANGKOK, June 23, 2022 / PRNewswire / – A startup under the umbrella of CU Innovation Hub in collaboration with the Chula Faculty of Science has developed an innovative Detachable and Dissolvable Microneedlethat makes any injections easy and painless for everyone, while also significantly reducing medical wastes.

Those needles and injections rejoice. Today, getting an injection is no longer scary or painful, because people have a “Detachable and Dissolvable Microneedle“, an innovative microneedle patch that can be implanted, fully detached, and dissolved under skin. A product from Mineed Technology Co.Ltd.., a startup under the umbrella of the Innovation Hub of Chulalongkorn University (CU Innovation Hub) with Prof. Dr. Supason WanichwecharraungDepartment of Chemistry, Faculty of Science, Chulalongkorn University.

“Injection is one form of a typical treatment and prophylaxis that everyone has to deal with, whether it’s vaccination, insulin for diabetics treatment, or even typical injections to treat facial acnes. distress, in some cases, severe physical trauma, such as hyperhidrosis patients, who would require 30 injections under each armpit, “Prof. Supason explained about the kickoff ideas of the microneedle patch.

From Problems to the Development of “Detachable and Dissolvable Microneedles”

Microneedles were invented and have been used globally for a while, but they have not been as popular as they should be. Prof. Supason revealed the problem of the previous generation of microneedles “the needles do not dissolve immediately so that it is left up to 2-6 hours. in the needles to absorb at a different rate, do not completely dissolve, or do not penetrate the skin of the users. “

“So, we have developed this innovation that once the needle patch is in place, the implanted need can be instantly detached itself into the skin, like implanting a splinter into human skin, but in this case, it doesn’t hurt, 100% safe, and a lot quicker than other typical dissolving microneedles. “

Small but Full-performance Needles

The innovative microneedle contains less than 1 millimeter (1,000 microns). It can quickly dissolve into the skin giving a different sensation than an injection with a typical syringe.

Mr. Chokchai Puangsiri, Director of Business Development, Mineed Technology Co.Ltd.., who often tried the microneedle, described the experience of using the patches, “Although it feels like something is touching the skin, it feels more like a typical syringe injection, more like touching the prickly part of the velcro tape. The microneedles can also be self-administered anytime, anywhere without the need for any medical expert anymore. “

Another benefit of using microneedles is that the dosage of medication is much lower. Prof. Dr. Supason gave the example of the COVID-19 vaccination, “T.here are two types of COVID-19 vaccinations, intramuscular vaccinations, and subcutaneous vaccinations. “Subcutaneous injections are better at stimulating the immune system while using lower doses than intramuscular injections, but subcutaneous injections are more difficult to inject and, if done frequently, it can cause scarring.”

The innovative soluble microneedles, therefore, make subcutaneous injections and simply eliminate the likelihood of “scarring” from syringes, especially among patients who need regular subcutaneous injections, such as diabetics. Also, dissolving microneedles help greatly reducing the amount of hazardous medical waste like needles and syringes as well.

Microneedles are easy to use. Anyone can give themselves the injection.

Microneedles cater to those who need frequent subcutaneous injections so they don’t have to waste their time and money traveling to receive services from healthcare profession. It is also suitable for those who need them or do not dare to give themselves injections.

In the past, many diabetic patients died because they did not dare give themselves insulin injections, and therefore, were not properly treated. Therefore, microneedles are the answer for this group of people, because patients can inject themselves easily. “

Microneedles also help extend drugsshelf life2 more years. “

With various microneedle properties, Mr. He said the innovation will help the healthcare profession in providing telemedicine services without patients having to come to the hospitals for their future injections, which is really cost effective.

How to use “Detachable and Dissolvable Microneedles”

The Detachable and Dissolvable Microneedle set consists of two components: a microneedle patch, and a moisture patch resembling a wet tissue. The application starts with placing the microneedle patch on the skin where the injection is needed. Use fingers to press all over the sheet so the needle contains the drug is embedded under the skin. Place the wet patch over the microneedle patch to dissolve it. Leave it for at least 2 minutes for those who need to be detached and dissolved under the skin. Then, peel off the wet and microneedle patches, and it’s done – both conveniently and quickly.

For people who are worried about allergic reactions, Prof. Dr. Supason explainedT.he microneedle is made from hyaluronic acid, which is a polymer that already exists in any human body, so it surely doesnt cause any allergic reaction. The needle can be used by anyone, but it also depends on the type of drug or vaccine that is injected. If the user is allergic to the drug or vaccine, it is inevitable that there is a chance for an allergic reaction. “

Group of medicines suitable for microneedles

Microneedles can be used subcutaneously, whether they are topical, as as antiacne, antikeloid scarring medicines, or drugs for bodily systems, such as diabetes, migraine, contraception, etc.

“In our Detachable and Dissolvable Microneedles, we can precisely control the dosage, the depth of the skin layer to be injected, and the time for dissolution rate appropriate to the drugs,” Mr. They chokchai.

Unsuitable drug types for microneedles are those with high dosage, because of the limited size of patches and needles making them too small for high-dose drugs. The proper dose is 1 mg per square centimeter.

Marketing opportunities for microneedles

Mr. Chokchai mentioned that the current development of microneedles is for two markets: the cosmetics market and the pharmaceutical market.

In the cosmetics market, hospitals and cosmetology clinics, both local and overseas, have already been licensed and used by the microneedles Thailand and Europe, with vitamins and skincare agents. In the future, microneedles can commission the company to develop microneedles.

For the pharmaceutical market, the process is at the Proof of Concept stage, and clinical trials are in collaboration with the partners before the products are launched at general pharmacies.

“We tested a variety of medications, such as anti-inflammatories for the skin, acne medicines, and blood-glucose-lowering medicines for diabetics, and it worked well. regulations, “Chokchai said.

The innovative Detachable and Dissolvable microneedles can be developed for many types of medicines, such as herbal patches for mosquito bites. The characteristics and components of the microneedles can also be adapted to the performance of any specific medicines, such as the size of the needle, or the duration of dissolution.

Dissolvable microneedles will give people wider access to treatment and preventive medicine because there’s no need to need or pain any longer. Now, needles are only minute matters.

Minerals Technology Co., Ltd..Ltd.. Tel. +66969748855 (Mr. Chokchai) or visit https://mineed.tech/

For the full release and more images, please visit: https://www.chula.ac.th/en/highlight/73232/

About Chulalongkorn University

Chulalongkorn University sets the standard as a university of innovations for society and is listed in the World’s Top 100 Universities for Academic Reputation, in the Quacquarelli Symonds (QS) World University Rankings 2021.

For more info about this topic, please contact Miss Thanita Wangvanichapan at (+66) 2218 3280 or email [email protected]

SOURCE Chulalongkorn University

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