Research reveals stress, anxiety, depression during pregnancy can impair cognitive development in infants

May 22, 2022 14:48 IST

Washington [US]May 22 (ANI): According to new research at Children’s National Hospital, stress, anxiety, and depression affect the pregnant women in basic aspects of the fetal brain, resulting in a reduction in cognitive development in children at 18 months of age.
The findings of the research were published in the journal ‘JAMA Network’.
Researchers followed a cohort of 97 pregnant women and their babies. The changes also increase internalization and dysregulation behavior. The findings further suggest that persistent psychological distress may affect the child’s child-parent interaction and infant self-regulation.
This is the first study to shed light on an important link between altered in-utero fetal brain development and the long-term cognitive development consequences for fetuses exposed to high levels of toxic stress during pregnancy. While in the womb, the researchers observed changes in the sulcal depth and left hippocampal volume, which could explain the neurodevelopment issues seen after birth.
Once they grow into toddlers, these children may experience persistent social-emotional problems and have difficulty establishing positive relationships with others, including their mothers. To further confirm this, future studies with a larger sample size that reflect more regions and populations are needed.

“By identifying pregnant women with elevated levels of psychological distress, clinicians could identify those babies who are at risk for later neurodevelopmental impairment and possibly benefit from early, targeted interventions,” said Catherine Limperopoulos, Ph.D., chief, and director of. The Developing Brain Institute at Children’s National and Senior Author of the study.
Regardless of their socioeconomic status, about one in every four pregnant women suffers from stress-related symptoms, the most common pregnancy complication. The relationship between altered fetal brain development, prenatal maternal psychological distress, and long-term neurodevelopmental outcomes remains unknown.
Studying in utero fetal brain development poses challenges to fetal and maternal movements, imaging technology, signal-to-noise ratio issues, and changes in brain growth.
All pregnant participants were healthy, had some level of education, and were employed. To quantify prenatal maternal stress, anxiety, and depression, the researchers used validated self-reported questionnaires.
Fetal brain volumes and cortical folding were measured from three-dimensional reconstructed images derived from MRI scans. Fetal brain creatine and choline were quantified using proton magnetic resonance spectroscopy. The 18-month-old child’s neurodevelopment was measured using validated scales and assessments.
This study builds on previous work from the Brain Institute led by Limperopoulos, which discovered that anxiety in pregnant women appears to affect their brain development of their babies. Her team also found that maternal mental health, even for women with high socioeconomic status, alters the structure and biochemistry of the developing fetal brain. The growing evidence underscores the importance of mental health support for pregnant women.
“We’re looking at shifting the health care paradigm and adopting these changes more broadly to better support moms,” said Limperopoulos. “What’s clear is early interventions could help moms reduce their stress, which can positively impact their symptoms and thereby give their baby a long after-birth.” (ANI)

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