Scarless skin grafting using mussel adhesive protein – ScienceDaily

One of the biggest concerns for patients undergoing skin grafting is scarring post-surgery and the regeneration of transplanted skin. The depth of scarring after suturing varies depends on the skill of the medical personnel performing the skin grafting, and wound healing at the suture site requires over a month. Recently, a Korean research team has drawn attention to developing a bioadhesive based on the mussel adhesive protein (MAP) that enables quick healing of wounds with minimal scarring. Skin transplantation using this adhesive can effectively revive skin without using sutures.

A research team led by Professor Hyung Joon Cha, Woo Hyung Park and Ph.D. Candidate Jae Yun Lee from the Department of Chemical Engineering at POSTECH has developed a bioadhesive for skin grafting involving two types of drugs. Hyo Jeong Kim of the Korea Research Institute of Chemical Technology.

These research findings, proposing a new system for scarless skin grafting, were recently published in the Chemical Engineering JournalGeneral Chat Chat Lounge

The research team developed the bioadhesive by introducing allantoin and epidermal growth factor into a mussel adhesive protein coacervate. Upon application of this bioadhesive, the two drugs are successfully released, according to the stage of the wound healing process, and regenerate the skin.

Results of the study suggest that the wound area recovered more efficiently than when treated with sutures used in current skin grafting. In particular, the transplanted area of ​​the hair follicles was minimal, while collagen and major skin factor levels were effectively revived.

A characteristic of this bioadhesive is that it unlike sutures, it leaves minimal scarring on the wound area and is harmless to the human body because it utilizes mussel adhesive protein, a biomaterial.

Professor Hyung Joon Cha explained, “We used the mussel adhesive protein – a biomaterial that originated in Korea – in the newly developed bioadhesive for skin grafting that resulted in minimal scarring and promoted skin regeneration.” He added, “This new system will be effectively implemented in the transplantation of various affected areas requiring tissue regeneration.”

This study was supported by the Health Technology Research and Development Project of the Ministry of Health and Welfare of Korea. The technology of the mussel adhesive protein (MAP) has undergone a technology transfer to Nature Gluetech Co. Ltd, and among these, “FIxLight,” a medical adhesive for extra-epidermal soft tissue, is undergoing human clinical trials. The commercialization and development of the medical adhesive coacervate is in progress.

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Materials provided by Pohang University of Science & Technology (POSTECH)General Chat Chat Lounge Note: Content may be edited for style and length.

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